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Indonesian Journal of Pharmaceutical and Clinical Research

idjpcr
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Published by Universitas Sumatera Utara

ISSN : 26156199 EISSN : 26203731 DOI : https://doi.org/10.32734/idjpcr.v1i1.203

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) is a-peer-reviewed publication of original research works. The mission of the journal is to offer a medium to exchange ideas and information about the advancement of knowledge and research in disciplines of pharmaceutical technology, pharmacology, clinical pharmacy, medical sciences, biological pharmacy and pharmaceutical chemistry. The journal also receives systematic reviews, meta-analysis and review article on new issues in pharmaceutical and clinical sciences. Submission to this journal implies that the manuscript has not been published or under consideration to be published in another journal. At the initial stage, this journal will be published online twice a year.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 8 Documents

Search results for , issue "Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research" : 8 Documents clear

Determination of Heavy Metal Contaminations of Lead and Cadmium in Selected Lipstick Products Sold in Padang City Using Atomic Absorption Spectrophotometry Ridho Asra; Rusdi; Robi Budi Yandra; Nessa
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

The study was aimed at assessing the levels of some toxic metals of lead and cadmium in selected lipstick products sold in Padang city. Four brands of lipsticks were taken which were BL, NK, PS and WD. The lipsticks were grinded and analyzed for heavy metals (lead and cadmium) using atomic absorption spectrophotometry. Each sample was destructed by nitric acid and perchloric acid (3:1). Destructed samples were added with sodium hydroxide to liberate ammonia and filtered into a 25 mL volumetric flask. The concentrations of heavy metal were measured by using atomic absorption spectrophotometry. The results showed that lead heavy metal contamination was not detected. Whereas, the heavy metal contamination of cadmium in lipstick brands BL, NK, PS and WD were 0.2287, 0.2000, 0.1796 and 0.1220 mg/kg, respectively. The study results showed that all metal contaminations of lead and cadmium were not over the limit which were regulated by National Agency of Drug and Food Control of the Republic of Indonesia.

Antibacterial Activities of Perfume: Combination Flower Magnolia alba, Cananga odorata and Mimusops elengi L, Fixed with Pogostemon cablin Oil Nasution, Rosnani; Azwar, Azalia Izdhihar; Helwati, Hira; Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Abstract: The making of perfume from the combination Magnolia alba (M. alba) flower oil, Cananga odorata (C. odorata) and Mimusops elengi L (M. elengi) fixed with Pogostemon cablin oil (P. cablin) have been done. Essential oil of M. alba and C. odorata was distilled by water distillation and extraction essential oil of M. elengi flower using n-hexane evaporated solvent method. Composition perfume through organoleptic test obtained with a ratio of 4% v/v, 4% v/v, and 2% v/v for each essential oil M. alba, C. odorata and M. elengi. Antibacterial activity of the perfume and each of the volatile oil was performed by the disc diffusion method. Antibacterial activity test showed that perfumes were able to inhibit the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria, but less active. Antibacterial activity of the perfume was more active against E. coli with an inhibitory zone of 8.3 mm and 39.81% inhibitory power than S. aureus bacterial 7.3 mm inhibition zone with 37.55% inhibitory power. Perfumes after storage for one, and two months had better antibacterial activity than before storage with an average inhibitory zone of 11-15 mm and inhibitory power of 50- 68,18%. Keywords: Antibacterial, E. Coli, C. Odorata, M. alba, M. elengi, P. cablin, , S. aureus

Mineral Analysis in Dioscorea hispida Dennst. Tuber by Atomic Absorption Spectrophotometry Masfria; Rehulina Gultom; Prayoga, Tedy
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

ABSTRACT Objective: The purpose of this study was to analyze minerals in gadung (Dioscorea hispida Dennst.) tuber. Method: The analysis of minerals was conducted by using atomic absorption spectrophotometry. Results: The results showed that the concentration of iron, cadmium, potassium, calcium, sodium, magnesium, copper and zinc were 0.6445 + 0.0029 mg/100g, 0.0011 + 0.0083 mg/100g, 265.2780 + 0.4652 mg/100g, 5.1015 + 0.0490 mg/100g, 8.3011 + 0.0974 mg/100g, 29.0237 + 0.0706 mg/100g, 0.1110 + 0.0019 mg/100g, and 0.6113 + 0.0026 mg/100g, respectively. Conclulsion: The gadung (Dioscorea hispida Dennst.) tuber contains iron, cadmium, potassium, calcium, sodium, magnesium, copper and zinc as the minerals.

Antibacterial Activity of Gel of Ethanol Extract of Papaya Leaves (Carica papaya L.) againts Propionobacterium acnes Pertiwi, Dewi; Ihsanul Hafiz; Rahmalia Salma
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Abstract Papaya plants (Carica papaya L) besides being a food ingredient are also believed to have medicinal properties and are used traditionally, one of which is in dealing with acne problems. The purpose of this study was to formulate papaya leaf extract in the form of a gel preparation and test its antibacterial activity against the Propionibacterium acnes bacteria. The preparation of the ethanol extract of papaya leaves was made in three concentrations namely 5, 10 and 15%, then tested for antibacterial activity and compared with negative controls (blank gel) and positive control (erythromycin). The results showed that the papaya extract ethanol extract of 10 and 15% leaves had significantly different activities to the negative controls, but the 5% gel formula did not show any different activity towards negative controls. The conclusion of this study is that active papaya leaf ethanol extract gel inhibits bacterial growth at concentrations of 10 and 15%. Keywords: Carica papaya L., gel formula, antibaterial activity, Propionibacterium acnes

The Effect of Turmeric Extract (Curcuma Domestica Val) Against the Durability of Yellow Rice Storage Maha, Hetty Lendora; Sitompul, Erly; silalahi, Jansen
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Yellow cooked rice is a traditional food in some regions in Indonesia. Yellow cooked rice with the addition of turmeric and flavoring which can longer shelf life of savings because it has antibacterial activity and flavor. The purpose of this study was to determine the effect of turmeric extract (Curcuma domestica Val) to extend shelf life of yellow cooked rice. The samples used were made of yellow cooked rice with handmade and without any seasoning flavored with turmeric extract concentration of 1.8% and 2.4%. Organoleptic testing were conducted every 3 hours, test of microbial growth daily and inhibition of turmeric extract with a concentration of 1.8% and 2.4% of fungi isolated from yellow cooked rice with a total plate count method. Research showed that turmeric extract concentration and the addition of herbs affect the longer shelf life of yellow cooked rice store. High more and more concentration of the turmeric extract can made longer the shelf life of yellow cooked rice either through organoleptic and also total plate count. Yellow cooked rice without seasoning with turmeric extract concentration of 1.8% and 2.4% were 30 and 33 hours respectively, while the yellow cooked rice was flavored with the same concentration of turmeric extract were 36 and 39 hours respectively.

Antibacterial Activity of Ethyl Acetate Fraction of Passion Fruit Peel (Passiflora Edulis Sims) on Staphylococcus Aureus and Escherichia Coli Nugraha, Sony Eka; Suryadi Achmad; Erly Sitompul
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

North Sumatera is one of the central areas of purple passion fruit production in Indonesia. Processing passion fruit into beverage products (passion fruit juice) produces peel has not been utilized. The use of passion fruit skin needs to be studied so that it can be useful as a raw material for antibacterial drug preparations. The aim of this study was to determine the phytochemical constituent screening and antibacterial activity of ethyl acetate fraction of purple passion fruit peel against Staphylococcus aureus and Escherichia coli. Simplicia and ethyl acetate fraction were determinated its phytochemical properties. The extraction process by percolation method using ethanol 96% and continue to fractionation process by liquid liquid extraction method using n-hexane and ethyl acetate. The antibacterial activity were tested against Staphylococcus aureus and Escherichia coli using agar diffusion method with paper discs. The result showed that the simplicia characteristic of passion fruit peel were water content of 8.64%, water soluble extract of 31.69%, ethanol soluble extract of 13.02%, ash total of 7.89%, and insoluble ash in acid of 0.816%. The phytochemical screening simplicia and ethyl acetate fraction showed the presence of flavonoids, glycosides, saponins and tannins. The antibacterial activity test showed that the ethyl acetate fraction has an effective inhibition at the concentration of 100 mg/ml against Staphylococcus aureus and Escherichia coli, it showed dose dependent manner. The ethyl acetate fraction of passion fruit peel (Passiflora edulis Sims) has an antibacterial activity on Staphylococcus aureus and Escherichia coli

Appropriateness of Antibiotic Utilization in Hospitalized Post-Surgery Patients Nasution, Azizah; Fashilah, Noor; Nugraha, Sony Eka
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Abstract. One of the most common health problems related to surgery is infection which needs treatment with antibiotics. Inappropriate use of antibiotics results in many problems including microbial resistance, interference of the required clinical outcomes, increasing side effects of the provided antibiotics and health resources utilization, causing toxic effects to the body organs, and even death. This study aimed to evaluate the appropriateness of antibiotic utilization on post-surgery patients admitted to Haji Adam Malik (HAM) Hospital, Medan, Indonesia. This three-month prospective descriptive study was conducted to evaluate the appropriateness of antibiotic utilization based on Gyssens method categorized into appropriate and inappropriate (in terms of dose, interval, route, too long provision, too short provision, less effective, toxicity, price, and the spectrum), and trustable literatures on post-surgery patients assessed from their medical records (n=31) in HAM Hospital Medan. Most (54.8%) of the patients were females. The study proved that 23 (74.2%) of the patients received appropriate/rational antibiotic therapy and 8 (25.8%) of them received inappropriate antibiotic therapy consisted of problems with: inappropriate dose, 13%; too long duration, 3.2%); too short duration, 29%. More than a quarter of the patients received inappropriate dosages of antibiotics.

Potential Medication Errors in Electronic Prescribing in A Primary Health Care Nurfitria, Rizki Siti; Adillah Effendi , Rima Nur; Iskandar , Deni
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

An effort to reduce medication errors is to use drugs prescription electronically[1,2,4]. However, there needs to be an evaluation of this system, because this system is not free from errors in medication. This study aimed to find out the description of prescribing flow, to examine electronic prescription completeness, and find out the potential medication errors that occur in the prescribing phase of electronic prescription using prescribing indicators[1,5,9,10]. This study used observational method by taking general practice outpatient prescription data of March 2018 in a company health service located in Bandung and analyzed descriptively[6,7,8]. Electronic prescription of medicines at this health care was made and inputted by doctors. When an error occured on a computer system, the doctor would prescribe it manually so that the patient can still be served. Incompleteness of the most common recipe was on administrative requirements where all prescriptions did not listed the doctor's practice permit, patient's gender, patient's weight, telephone number of the place of practice, and patient's contact number. Medication errors had the most potential for the occurrence of prescription writing with two or more drugs interacting and this error was classified as category D according to The National Coordinating Council for Medication Error Reporting and Prevention (NCC-MERP).

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Reviewer

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Contact Name
Sony Eka Nugraha

Contact Email
Idkpcr@usu.ac.id

Phone
+62823 7049 2800

Journal Mail Official
idjpcr@usu.ac.id

Editorial Address
TALENTA Publisher Universitas Sumatera Utara cq.Indonesian Journal of Pharmaceutical and Clinical Research Faculty of Pharmacy Univesitas Sumatera Utara Jalan Tri Dharma No. 5, Pintu 4, Kampus USU Padang Bulan Medan 20155, Sumatera Utara - Indonesia

Location
Kota medan,

Sumatera utara

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Sony Eka Nugraha

Contact Email Idkpcr@usu.ac.id

Phone +62823 7049 2800

Journal Mail Official idjpcr@usu.ac.id

Editorial Address TALENTA Publisher Universitas Sumatera Utara cq.Indonesian Journal of Pharmaceutical and Clinical Research Faculty of Pharmacy Univesitas Sumatera Utara Jalan Tri Dharma No. 5, Pintu 4, Kampus USU Padang Bulan Medan 20155, Sumatera Utara - Indonesia

Location Kota medan, Sumatera utara INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Sony Eka Nugraha

Contact Email
Idkpcr@usu.ac.id

Phone
+62823 7049 2800

Journal Mail Official
idjpcr@usu.ac.id

Editorial Address
TALENTA Publisher Universitas Sumatera Utara cq.Indonesian Journal of Pharmaceutical and Clinical Research Faculty of Pharmacy Univesitas Sumatera Utara Jalan Tri Dharma No. 5, Pintu 4, Kampus USU Padang Bulan Medan 20155, Sumatera Utara - Indonesia

Location
Kota medan,

Sumatera utara

INDONESIA